Abstract
Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anthozoa / chemistry*
-
Diterpenes / chemistry*
-
Diterpenes / isolation & purification
-
Diterpenes / pharmacology
-
Enzyme Activation / drug effects
-
Humans
-
Magnetic Resonance Spectroscopy
-
Molecular Conformation
-
Neutrophils / drug effects
-
Pancreatic Elastase / metabolism
-
Superoxides / metabolism
Substances
-
6-epi-cladieunicellin F
-
Diterpenes
-
cladieunicellin G
-
Superoxides
-
Pancreatic Elastase