New 6-hydroxyeunicellins from a soft coral Cladiella sp

Chem Pharm Bull (Tokyo). 2012;60(1):160-3. doi: 10.1248/cpb.60.160.

Abstract

Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Enzyme Activation / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Neutrophils / drug effects
  • Pancreatic Elastase / metabolism
  • Superoxides / metabolism

Substances

  • 6-epi-cladieunicellin F
  • Diterpenes
  • cladieunicellin G
  • Superoxides
  • Pancreatic Elastase