Hemostatic multilayer coatings

Adv Mater. 2012 Jan 24;24(4):492-6. doi: 10.1002/adma.201103794. Epub 2011 Dec 27.

Abstract

Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Gelatin / chemistry
  • Hemostasis / drug effects
  • Hemostatics / chemistry*
  • Hemostatics / pharmacology
  • Hydrogen Bonding
  • Polyphenols / chemistry
  • Static Electricity
  • Swine
  • Tannins / chemistry
  • Thrombin / chemistry
  • Water / chemistry

Substances

  • Hemostatics
  • Polyphenols
  • Tannins
  • Water
  • Gelatin
  • Thrombin