Abstract
Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Gelatin / chemistry
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Hemostasis / drug effects
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Hemostatics / chemistry*
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Hemostatics / pharmacology
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Hydrogen Bonding
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Polyphenols / chemistry
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Static Electricity
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Swine
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Tannins / chemistry
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Thrombin / chemistry
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Water / chemistry
Substances
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Hemostatics
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Polyphenols
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Tannins
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Water
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Gelatin
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Thrombin