Transcriptional priming of cytoplasmic post-transcriptional regulation

Transcription. 2011 Nov-Dec;2(6):258-62. doi: 10.4161/trns.2.6.18608. Epub 2011 Nov 1.

Abstract

Recent evidence suggests that post-transcriptional events that are executed in the cytoplasm can be predetermined during transcription. Here, I speculate that this is a widespread mode of regulation and discuss the potential mechanisms, advantages and implications of such a regulatory strategy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cytoplasm / metabolism*
  • Humans
  • Models, Genetic
  • Protein Binding
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism
  • Transcription, Genetic*

Substances

  • RNA, Messenger
  • RNA-Binding Proteins