Abstract
Diethazine, amitriptyline and imipramine showed bacteriostatic and bactericidal effect on different bacteria. Chlorpromazine sulphoxide and fluorescein were ineffective even at 1000 microgram/ml. The antibacterial compounds deleted at 40-70% frequency the F'lac plasmid of Escherichia coli K12 LE-140.
MeSH terms
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Antidepressive Agents, Tricyclic / pharmacology*
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Antipsychotic Agents / pharmacology*
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Bacteria / drug effects
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Cell Division / drug effects
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Escherichia coli / drug effects*
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Lactose Factors / drug effects*
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Phenothiazines
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Plasmids / drug effects*
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Structure-Activity Relationship
Substances
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Antidepressive Agents, Tricyclic
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Antipsychotic Agents
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Phenothiazines