Abstract
Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / administration & dosage*
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Antibiotics, Antineoplastic / pharmacology
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Cell Survival / drug effects
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Doxorubicin / administration & dosage*
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Doxorubicin / pharmacology
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Drug Carriers / chemistry*
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Female
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Humans
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Nanostructures / chemistry*
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Nanostructures / ultrastructure
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Zirconium / chemistry*
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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zirconium phosphate
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Doxorubicin
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Zirconium