Humanized mice as a preclinical tool for infectious disease and biomedical research

Ann N Y Acad Sci. 2011 Dec:1245:50-4. doi: 10.1111/j.1749-6632.2011.06310.x.

Abstract

Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Communicable Diseases / etiology*
  • Disease Models, Animal
  • HLA Antigens / genetics
  • Humans
  • Interleukin Receptor Common gamma Subunit / deficiency
  • Interleukin Receptor Common gamma Subunit / genetics
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Mice, Transgenic
  • Models, Immunological
  • Neoplasms / therapy
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / immunology
  • Regenerative Medicine
  • T-Lymphocytes / immunology
  • Transplantation Chimera / immunology

Substances

  • HLA Antigens
  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit
  • Ptpns1 protein, mouse
  • Receptors, Immunologic