Abstract
Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma. However, the incidences of A20 abnormalities and their clinical impact remain for the most part unknown. It is also unknown whether ABIN-1 and ABIN-2, the components of the A20 NF-κB inhibitor complex, are inactivated by genetic changes in ocular adnexal mucosa-associated lymphoid tissue lymphoma. A total of 105 cases were investigated for A20 mutation/deletion, ABIN-1/2 mutation, MALT1 and IGH involved translocation. Somatic mutation was seen frequently in A20 (28.6%) but rarely in ABIN-1 (1%) and ABIN-2 (1%). A20 mutations were significantly associated with A20 heterozygous deletion, and both were mutually exclusive from the MALT1 or IGH involved translocations. A20 mutation/deletion was also significantly associated with increased expression of the NF-κB target genes CCR2, TLR6 and BCL2. The cases with A20 mutation/deletion required significantly higher radiation dosages to achieve complete remission than those without these abnormalities.
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Aged
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Amino Acid Sequence*
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Caspases / genetics
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DNA-Binding Proteins / genetics*
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Eye Neoplasms / genetics*
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Eye Neoplasms / radiotherapy
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Female
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Gene Expression*
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Heterozygote
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Humans
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Intracellular Signaling Peptides and Proteins / genetics*
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Lymphoma, B-Cell, Marginal Zone / genetics*
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Lymphoma, B-Cell, Marginal Zone / radiotherapy
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Male
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Middle Aged
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Molecular Sequence Data
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
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NF-kappa B / genetics
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Neoplasm Proteins / genetics
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Nuclear Proteins / genetics*
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Radiation, Ionizing
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Receptors, CCR2 / genetics
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Sequence Deletion*
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Toll-Like Receptor 6 / genetics
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Translocation, Genetic
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Tumor Necrosis Factor alpha-Induced Protein 3
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bcl-Associated Death Protein / genetics
Substances
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Adaptor Proteins, Signal Transducing
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CCR2 protein, human
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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NF-kappa B
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Neoplasm Proteins
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Nuclear Proteins
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Receptors, CCR2
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TLR6 protein, human
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TNIP1 protein, human
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TNIP2 protein, human
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Toll-Like Receptor 6
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bcl-Associated Death Protein
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TNFAIP3 protein, human
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Tumor Necrosis Factor alpha-Induced Protein 3
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Caspases
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MALT1 protein, human
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein