Hyaluronic acid fillers: history and overview

Facial Plast Surg. 2011 Dec;27(6):523-8. doi: 10.1055/s-0031-1298785. Epub 2011 Dec 28.

Abstract

Hyaluronic acid (HA) fillers have many favorable characteristics that make it a popular injectable filler device. Its minimal immunogenicity and relative ease of use has helped HA become the most commonly used injectable filler today. A brief history of injectable fillers, the various injection techniques, and legal ramifications are discussed. A review of the most recent literature compares the efficacy and safety of HA to other injectable filler substances.

Publication types

  • Comparative Study
  • Historical Article
  • Review

MeSH terms

  • Biocompatible Materials / history
  • Biocompatible Materials / therapeutic use*
  • Cosmetic Techniques* / history
  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Hyaluronic Acid / analogs & derivatives
  • Hyaluronic Acid / history
  • Hyaluronic Acid / therapeutic use*
  • Injections, Intradermal

Substances

  • Biocompatible Materials
  • Juvederm Ultra
  • Hyaluronic Acid
  • Restylane