Abstract
This manuscript describes cell-uptake studies with HEK 293T cells on a series of ruthenium complexes shown previously to act as receptors for protein surface recognition and was motivated by a desire to establish if these receptors represent suitable templates for further elaboration as inhibitors of protein-protein interactions. The results illustrate that large (>3000Da) highly functionalized anionic ruthenium complexes are efficiently transfected via endocytosis to lysosomes with negligible toxicity.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2,2'-Dipyridyl / analogs & derivatives*
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2,2'-Dipyridyl / chemical synthesis
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2,2'-Dipyridyl / chemistry
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2,2'-Dipyridyl / pharmacokinetics
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Cell Survival / drug effects
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Coordination Complexes
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Dose-Response Relationship, Drug
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Endocytosis / drug effects
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HEK293 Cells
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Humans
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Lysosomes / drug effects
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Molecular Mimicry / drug effects*
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Molecular Structure
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Protein Binding / drug effects
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Structure-Activity Relationship
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Surface Properties
Substances
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Coordination Complexes
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tris(2,2-bipyridine)-ruthenium(II)
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2,2'-Dipyridyl