[Candidal carriage and the development of invasive candidiasis of the organs of the digestive tract during experimental immunodepression]

Abstract

After infecting healthy mice with Candida by their oral administration the fungi are rapidly eliminated from the digestive tract. In the animals, immunosuppressed by the injection of cyclophosphamide, the prolonged persistence of Candida in the digestive tract occurs, and the administration of Candida in considerable doses over prolonged periods in combination with the injections of high doses of immunosuppressing agents results in the development of profound invasive lesions, in some cases leading to the dissemination of the process.