Formal intermolecular [2 + 2] cycloaddition reaction of allenamide [corrected] with alkenes via gold catalysis

Xiao-Xiao Li; Li-Li Zhu; Wen Zhou; Zili Chen

doi:10.1021/ol202703a

Formal intermolecular [2 + 2] cycloaddition reaction of allenamide [corrected] with alkenes via gold catalysis

Org Lett. 2012 Jan 20;14(2):436-9. doi: 10.1021/ol202703a. Epub 2011 Dec 27.

Authors

Xiao-Xiao Li¹, Li-Li Zhu, Wen Zhou, Zili Chen

Affiliation

¹ Department of Chemistry, Renmin University of China, Beijing 100872, China.

PMID: 22201372
DOI: 10.1021/ol202703a

Abstract

An efficient method was developed to construct the densely functionalized cyclobutane[corrected] adducts through formal intermolecular cycloaddition of allenamides [corrected] with electron-rich olefins via gold catalysis, in which vinyl ethers/amides and electron-rich styrenes worked very well. In addition, a series of allenamide [corrected] dimerization products were prepared from the same allenamide [corrected] substrates.