Abstract
Demyelinating diseases were described in patients receiving anti-TNF agents. Optic neuritis (ON) induced by TNF blockers was already described in 22 cases in the literature. In this article, the authors report a 53-year-old woman with refractory rheumatoid arthritis that developed neuritis optica after the fourth dose of infliximab and had a good outcome after anti-TNF withdrawal, associated with glucocorticoid treatment. In addition, the previous cases of ON induced by anti-TNF agents were reviewed.
MeSH terms
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal / therapeutic use
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Antirheumatic Agents / adverse effects*
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Antirheumatic Agents / therapeutic use
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Arthritis, Rheumatoid / drug therapy*
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Female
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Humans
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Immunologic Factors / adverse effects*
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Immunologic Factors / therapeutic use
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Infliximab
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Middle Aged
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Optic Neuritis / chemically induced*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Antibodies, Monoclonal
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Antirheumatic Agents
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Immunologic Factors
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Tumor Necrosis Factor-alpha
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Infliximab