Antithrombotic phenolic compounds from Glycyrrhiza uralensis

Fitoterapia. 2012 Mar;83(2):422-5. doi: 10.1016/j.fitote.2011.12.010. Epub 2011 Dec 14.

Abstract

A new coumestan, named glycyrurol, and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative assay found significant antithrombotic activity of compounds 4, 8 and 10.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticoagulants / chemistry
  • Anticoagulants / isolation & purification
  • Anticoagulants / pharmacology*
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / pharmacology*
  • Dose-Response Relationship, Drug
  • Glycyrrhiza uralensis / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry
  • Rhizome / chemistry

Substances

  • Anticoagulants
  • Coumarins
  • Heterocyclic Compounds, 4 or More Rings
  • Phenols
  • Plant Extracts
  • coumestan