Abstract
A new coumestan, named glycyrurol, and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative assay found significant antithrombotic activity of compounds 4, 8 and 10.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticoagulants / chemistry
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Anticoagulants / isolation & purification
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Anticoagulants / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Dose-Response Relationship, Drug
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Glycyrrhiza uralensis / chemistry*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Molecular Structure
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Phenols / chemistry
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Phenols / isolation & purification
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Phenols / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots / chemistry
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Plants, Medicinal / chemistry
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Rhizome / chemistry
Substances
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Anticoagulants
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Coumarins
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Heterocyclic Compounds, 4 or More Rings
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Phenols
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Plant Extracts
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coumestan