Specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation

J Control Release. 2011 Nov 30:152 Suppl 1:e227-9. doi: 10.1016/j.jconrel.2011.09.027.

Authors

Hong Yang¹, Lie Zhang, Xiaoyang Xiong, Yiyao Liu

Affiliation

¹ Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

PMID: 22195873
DOI: 10.1016/j.jconrel.2011.09.027

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / chemistry
Antibodies, Monoclonal / metabolism*
Atherosclerosis / diagnostic imaging
Atherosclerosis / immunology
Atherosclerosis / metabolism*
Atherosclerosis / physiopathology
Biotinylation
Cells, Cultured
Disease Models, Animal
Drug Carriers*
Endothelial Cells / drug effects
Endothelial Cells / metabolism*
Hemodynamics*
Human Umbilical Vein Endothelial Cells / metabolism
Humans
Inflammation / diagnostic imaging
Inflammation / immunology
Inflammation / metabolism*
Inflammation / physiopathology
Ligands
Lipids / chemistry*
Lipopolysaccharides / pharmacology
Microbubbles*
Particle Size
Rats
Stress, Mechanical
Ultrasonography
Vascular Cell Adhesion Molecule-1 / immunology
Vascular Cell Adhesion Molecule-1 / metabolism*

Substances

Antibodies, Monoclonal
Drug Carriers
Ligands
Lipids
Lipopolysaccharides
Vascular Cell Adhesion Molecule-1