Biosynthesis of 3,5-AHBA-derived natural products

Nat Prod Rep. 2012 Feb;29(2):243-63. doi: 10.1039/c2np00019a. Epub 2011 Dec 22.

Abstract

Covering: 1957 to 2011. 3-Amino-5-hydroxy benzoic acid (3,5-AHBA) is a precursor for a large group of natural products, including the family of naphthalenic and benzenic ansamycins, the unique saliniketals, and the family of mitomycins. This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinomycetales / enzymology
  • Actinomycetales / genetics
  • Aminobenzoates / chemistry*
  • Biological Products / chemistry
  • Biological Products / metabolism*
  • Biosynthetic Pathways / physiology*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Hydroxybenzoates
  • Maytansine / biosynthesis*
  • Mitomycin / biosynthesis*
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Rifamycins / biosynthesis*

Substances

  • Aminobenzoates
  • Biological Products
  • Bridged Bicyclo Compounds, Heterocyclic
  • Hydroxybenzoates
  • Naphthoquinones
  • Rifamycins
  • saliniketal A
  • saliniketal B
  • Maytansine
  • Mitomycin
  • naphthomycin
  • 3-amino-5-hydroxybenzoic acid