Abstract
Covering: 1957 to 2011. 3-Amino-5-hydroxy benzoic acid (3,5-AHBA) is a precursor for a large group of natural products, including the family of naphthalenic and benzenic ansamycins, the unique saliniketals, and the family of mitomycins. This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Actinomycetales / enzymology
-
Actinomycetales / genetics
-
Aminobenzoates / chemistry*
-
Biological Products / chemistry
-
Biological Products / metabolism*
-
Biosynthetic Pathways / physiology*
-
Bridged Bicyclo Compounds, Heterocyclic / chemistry
-
Hydroxybenzoates
-
Maytansine / biosynthesis*
-
Mitomycin / biosynthesis*
-
Molecular Structure
-
Naphthoquinones / chemistry
-
Rifamycins / biosynthesis*
Substances
-
Aminobenzoates
-
Biological Products
-
Bridged Bicyclo Compounds, Heterocyclic
-
Hydroxybenzoates
-
Naphthoquinones
-
Rifamycins
-
saliniketal A
-
saliniketal B
-
Maytansine
-
Mitomycin
-
naphthomycin
-
3-amino-5-hydroxybenzoic acid