[Preparation of rat model of systemic inflammatory response syndrome induced by zymosan]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Nov;40(6):641-6. doi: 10.3785/j.issn.1008-9292.2011.06.011.
[Article in Chinese]

Abstract

Objective: To establish a model of systemic inflammatory response syndrome (SIRS) in rats.

Methods: SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.

Results: The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.

Conclusion: The rat model of systemic inflammatory response syndrome has been successfully induced.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Female
  • Interleukin-10 / blood
  • Interleukin-6 / blood
  • Male
  • Paraffin / toxicity
  • Rats
  • Rats, Sprague-Dawley
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / chemically induced*
  • Systemic Inflammatory Response Syndrome / pathology
  • Tumor Necrosis Factor-alpha / blood
  • Viscera / pathology
  • Zymosan / toxicity*

Substances

  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Paraffin
  • Zymosan