Serum procalcitonin value is useful for predicting severity of Kawasaki disease

Pediatr Infect Dis J. 2012 May;31(5):523-5. doi: 10.1097/INF.0b013e3182463879.

Abstract

We measured serum procalcitonin concentrations in 160 patients suffering from Kawasaki disease. Serum procalcitonin was significantly higher in nonresponders to an initial intravenous immunoglobulin treatment than in responders. A cutoff value of procalcitonin (0.5 ng/mL) for nonresponders showed that the sensitivity was 85% and the accuracy was 64%. Multivariate logistic regression analysis revealed that procalcitonin-positive cases showed the highest risk for nonresponders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome / diagnosis
  • Mucocutaneous Lymph Node Syndrome / physiopathology*
  • Mucocutaneous Lymph Node Syndrome / therapy
  • Predictive Value of Tests
  • Prognosis
  • Protein Precursors / blood*
  • Sensitivity and Specificity
  • Severity of Illness Index

Substances

  • CALCA protein, human
  • Immunoglobulins, Intravenous
  • Protein Precursors
  • Calcitonin
  • Calcitonin Gene-Related Peptide