Effect of Bixa orellana against Leishmania amazonensis

Forsch Komplementmed. 2011;18(6):351-3. doi: 10.1159/000335280. Epub 2011 Dec 9.

Abstract

Background: In the present study, an activity of Bixa orellana extract against Leishmania amazonensis was demonstrated.

Result: Experimentally infected BALB/c mice were treated with B. orellana extract which showed a significant activity against promastigote and amastigote forms of L. amazonensis.

Conclusion: This study supports the importance of natural sources as antileishmanial drugs.

MeSH terms

  • Amphotericin B / pharmacology
  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Antiprotozoal Agents / therapeutic use*
  • Bixaceae / chemistry*
  • Body Weight / drug effects
  • Cell Survival / drug effects
  • Female
  • Inhibitory Concentration 50
  • Leishmania / drug effects*
  • Leishmaniasis / drug therapy*
  • Life Cycle Stages / drug effects
  • Macrophages, Peritoneal / cytology
  • Macrophages, Peritoneal / parasitology
  • Mice
  • Mice, Inbred BALB C
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Random Allocation

Substances

  • Antiprotozoal Agents
  • Plant Extracts
  • Amphotericin B