Abstract
RNAs are underexploited targets for small molecule drugs or chemical probes of function. This may be due, in part, to a fundamental lack of understanding of the types of small molecules that bind RNA specifically and the types of RNA motifs that specifically bind small molecules. In this review, we describe recent advances in the development and design of small molecules that bind to RNA and modulate function that aim to fill this void.
MeSH terms
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Aminoglycosides / chemistry
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Aminoglycosides / metabolism
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / metabolism
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Antiviral Agents / pharmacology
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Bacteria / drug effects*
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Bacteria / growth & development
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Bacterial Infections / drug therapy
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Bacterial Infections / microbiology
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Binding Sites
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Drug Design
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Humans
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Inverted Repeat Sequences
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Molecular Sequence Data
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Nucleotide Motifs / genetics
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Protein Biosynthesis / drug effects
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RNA Viruses / drug effects*
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RNA Viruses / growth & development
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RNA, Bacterial / antagonists & inhibitors*
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RNA, Ribosomal, 16S / antagonists & inhibitors
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RNA, Viral / antagonists & inhibitors*
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Ribosome Subunits / drug effects
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Riboswitch / drug effects
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Small Molecule Libraries / chemistry*
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Small Molecule Libraries / metabolism
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Small Molecule Libraries / pharmacology
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Virus Diseases / drug therapy
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Virus Diseases / virology
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Antiviral Agents
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RNA, Bacterial
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RNA, Ribosomal, 16S
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RNA, Viral
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Riboswitch
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Small Molecule Libraries