[Role of repair gene polymorphism in estimating the sensitivity of human genome to radon in concentrations exceeding maximum permissible level]

V G Druzhinin; A N Volkov; A N Glushkov; T A Golovina; V I Minina; F I Ingel'; A V Larionov; A V Meĭer; A A Lunina; T A Tolochko; L V Akhal'tseva; E K Krivtsova; N A Iurtseva; V V Iurchenko

[Role of repair gene polymorphism in estimating the sensitivity of human genome to radon in concentrations exceeding maximum permissible level]

Gig Sanit. 2011 Sep-Oct:(5):26-30.

[Article in Russian]

Authors

V G Druzhinin, A N Volkov, A N Glushkov, T A Golovina, V I Minina, F I Ingel', A V Larionov, A V Meĭer, A A Lunina, T A Tolochko, L V Akhal'tseva, E K Krivtsova, N A Iurtseva, V V Iurchenko

PMID: 22184996

Abstract

The paper gives the results of investigating chromosome aberrations in human peripheral blood lymphocytes due to DNA repair genes, such as hOGG1, ADPRT, APE1, XRCC1, XpG, XpC, XpD, and NBS1, upon long-term exposure to excess indoor radon concentrations. The frequency of chromosome aberrations was found to be significantly lower in the carriers of the genotype hOGG1 326 Ser/Ser (versus the variant Ser/Cys), APE1 148 Asp/Asp (versus Val/Ala and Ala/Ala). The study polymorphic systems were shown to be of value in giving rise to individual types of chromosome aberrations (single fragments and chromosome exchanges).

Publication types

English Abstract

MeSH terms

Adolescent
Air Pollutants, Radioactive* / analysis
Air Pollution, Indoor* / analysis
Case-Control Studies
Child
Chromosome Aberrations / radiation effects*
Cohort Studies
DNA Repair / genetics*
Female
Genome, Human / radiation effects*
Humans
Lymphocytes / radiation effects
Male
Maximum Tolerated Dose
Polymorphism, Single Nucleotide*
Radon* / analysis
Seasons
Siberia

Substances

Air Pollutants, Radioactive
Radon