Translational vision research models program

Jungyeon Won; Lan Ying Shi; Wanda Hicks; Jieping Wang; Juergen K Naggert; Patsy M Nishina

doi:10.1007/978-1-4614-0631-0_50

Translational vision research models program

Adv Exp Med Biol. 2012:723:391-7. doi: 10.1007/978-1-4614-0631-0_50.

Authors

Jungyeon Won¹, Lan Ying Shi, Wanda Hicks, Jieping Wang, Juergen K Naggert, Patsy M Nishina

Affiliation

¹ The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

PMID: 22183357
DOI: 10.1007/978-1-4614-0631-0_50

Abstract

ENU mutagenesis is an efficient method to identify new animal models of ocular disease. The new alleles described herein will be a useful resource to further examine the role of the affected molecules and the effects of their disruption within the retina.

MeSH terms

Alkylating Agents / toxicity
Animals
Chromosome Mapping / methods
Cyclic Nucleotide Phosphodiesterases, Type 6 / genetics*
DNA Mutational Analysis / methods
Disease Models, Animal*
Ethylnitrosourea / toxicity
Eye Proteins / genetics*
Humans
Mice
Mice, Inbred C57BL*
Mutagenesis / physiology
Retinal Degeneration / chemically induced
Retinal Degeneration / genetics*
Rhodopsin / genetics*
Translational Research, Biomedical / methods

Substances

Alkylating Agents
Eye Proteins
Tulp1 protein, mouse
Rhodopsin
Cyclic Nucleotide Phosphodiesterases, Type 6
Pde6a protein, mouse
Ethylnitrosourea

Abstract

MeSH terms

Substances

Grants and funding