Abstract
A novel series of indolocarbazoles were synthesized and their antiproliferative activity against HUVEC, LoVo, DLD-1 and ST-486 cell lines, was investigated. Those staurosporine analogs in which a substituted dimethylaminoalkoxy chain was attached to the indolic nitrogen showed interesting activity and selectivity with respect to HUVEC proliferation. The effect on capillary tube formation in 3-dimensional matrigel matrix was studied using the most active compounds. Evaluation of their in vivo anti-angiogenic activity in a murine Lewis lung cancer model was also analyzed.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiogenesis Inhibitors / chemical synthesis*
-
Angiogenesis Inhibitors / chemistry
-
Angiogenesis Inhibitors / pharmacology
-
Animals
-
Capillaries / metabolism
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Collagen / pharmacology
-
Drug Combinations
-
Humans
-
Laminin / pharmacology
-
Lung Neoplasms / blood supply*
-
Lung Neoplasms / drug therapy*
-
Magnetic Resonance Spectroscopy
-
Mice
-
Molecular Structure
-
Neovascularization, Pathologic / drug therapy
-
Proteoglycans / pharmacology
-
Spectrophotometry, Infrared
-
Staurosporine / analogs & derivatives*
-
Staurosporine / chemical synthesis
-
Staurosporine / chemistry
-
Staurosporine / pharmacology
Substances
-
Angiogenesis Inhibitors
-
Drug Combinations
-
Laminin
-
Proteoglycans
-
matrigel
-
Collagen
-
Staurosporine