Sorafenib targets BCR kinases and blocks migratory and microenvironmental survival signals in CLL cells

Leukemia. 2012 Jun;26(6):1429-32. doi: 10.1038/leu.2011.364. Epub 2011 Dec 20.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzenesulfonates / pharmacology*
  • Blotting, Western
  • Cell Movement / drug effects*
  • Cell Survival
  • Chemokines / metabolism
  • Chemotaxis / drug effects
  • Humans
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Leukemia, Lymphocytic, Chronic, B-Cell / enzymology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Niacinamide / analogs & derivatives
  • Phenylurea Compounds
  • Protein Kinase Inhibitors / pharmacology*
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Pyridines / pharmacology*
  • RNA, Messenger / genetics
  • Real-Time Polymerase Chain Reaction
  • Receptors, Antigen, B-Cell / antagonists & inhibitors*
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / metabolism
  • Sorafenib
  • Syk Kinase
  • Tumor Cells, Cultured
  • Tumor Microenvironment / drug effects*
  • src-Family Kinases / antagonists & inhibitors
  • src-Family Kinases / genetics
  • src-Family Kinases / metabolism

Substances

  • Benzenesulfonates
  • Chemokines
  • Intracellular Signaling Peptides and Proteins
  • Phenylurea Compounds
  • Protein Kinase Inhibitors
  • Pyridines
  • RNA, Messenger
  • Receptors, Antigen, B-Cell
  • Niacinamide
  • Sorafenib
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • src-Family Kinases