Abstract
A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.
© 2011 John Wiley & Sons A/S.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Dehydroepiandrosterone / analogs & derivatives*
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Dehydroepiandrosterone / chemical synthesis
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Dehydroepiandrosterone / pharmacology*
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Neoplasms / drug therapy
Substances
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Antineoplastic Agents
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Dehydroepiandrosterone