Plasma levels of matrix metalloproteinase-9: a possible diagnostic marker of successful endovascular aneurysm repair

Eur J Vasc Endovasc Surg. 2012 Feb;43(2):171-2. doi: 10.1016/j.ejvs.2011.10.014. Epub 2011 Dec 14.

Abstract

Objective: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR).

Report: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak.

Conclusions: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angiography
  • Aortic Aneurysm, Abdominal / blood*
  • Aortic Aneurysm, Abdominal / surgery
  • Biomarkers / blood*
  • Blood Vessel Prosthesis Implantation*
  • Case-Control Studies
  • Endoleak / blood
  • Endoleak / diagnostic imaging
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Matrix Metalloproteinase 2 / blood
  • Matrix Metalloproteinase 9 / blood*
  • Middle Aged
  • Prospective Studies
  • Protease Inhibitors / blood
  • ROC Curve
  • Regression Analysis
  • Sensitivity and Specificity
  • Tissue Inhibitor of Metalloproteinase-1 / blood
  • Tomography, X-Ray Computed

Substances

  • Biomarkers
  • Protease Inhibitors
  • TIMP1 protein, human
  • Tissue Inhibitor of Metalloproteinase-1
  • MMP2 protein, human
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9