Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types

J Virol. 2012 Feb;86(4):2366-70. doi: 10.1128/JVI.06579-11. Epub 2011 Dec 14.

Abstract

The cutaneous beta human papillomavirus (beta HPV) types appear to be involved in skin carcinogenesis. However, only a few beta HPVs have been investigated so far. Here, we compared the properties of E6 and E7 oncoproteins from six uncharacterized beta HPVs (14, 22, 23, 24, 36, 49). Only HPV49 E6 and E7 immortalized primary human keratinocytes and efficiently deregulated the p53 and pRb pathways. Furthermore, HPV49 E6, similarly to E6 from the oncogenic HPV16, promoted p53 degradation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Betapapillomavirus / genetics
  • Betapapillomavirus / physiology*
  • Cell Transformation, Viral*
  • Cells, Cultured
  • Humans
  • Keratinocytes / virology
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / metabolism*
  • Papillomavirus E7 Proteins / genetics
  • Papillomavirus E7 Proteins / metabolism*
  • Papillomavirus Infections / genetics
  • Papillomavirus Infections / metabolism
  • Papillomavirus Infections / virology*
  • Signal Transduction
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Tumor Suppressor Protein p53