Pd-catalyzed olefination of furans and thiophenes with allyl esters

Yuexia Zhang; Zejiang Li; Zhong-Quan Liu

doi:10.1021/ol203013p

Pd-catalyzed olefination of furans and thiophenes with allyl esters

Org Lett. 2012 Jan 6;14(1):226-9. doi: 10.1021/ol203013p. Epub 2011 Dec 14.

Authors

Yuexia Zhang¹, Zejiang Li, Zhong-Quan Liu

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou Gansu 730000, PR China.

PMID: 22168263
DOI: 10.1021/ol203013p

Abstract

A direct Pd(II)-catalyzed olefination of furans and thiophenes with allyl esters is demonstrated. Under the typical conditions, the dehydrogenative Heck coupling reactions of heteroarenes with allylic esters proceeded via a β-H elimination rather than a β-OAc elimination to give the corresponding γ-substituted allylic esters.