Abstract
PEG-PLA copolymers with dumbbell- and Y-shaped structures are prepared. They can self-assemble from nanoparticles to micro-sized fusiform micellar particles in aqueous solution. In particular the micelles formed by the (PLA)2-PEG-(PLA)2 particles show a better drug loading capacity and encapsulation efficiency than those formed by linear MPEG-PLA. In vitro studies show that the particles formed by Y-shaped copolymers show a particularly quick drug release. The copolymers have good biocompatibility with low cytotoxicity. These unique self-assembled systems thus have many possible biomedical applications, such as a sustained delivery of high-dosed water insoluble drugs, quick effective drugs for trauma, controlled delivery of the oral-administration drugs, and so forth.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
BALB 3T3 Cells
-
Biocompatible Materials / chemical synthesis*
-
Biocompatible Materials / pharmacology
-
Cell Survival / drug effects
-
Delayed-Action Preparations / chemical synthesis*
-
Delayed-Action Preparations / pharmacology
-
Drug Carriers / chemical synthesis*
-
Drug Carriers / pharmacology
-
Drug Compounding / methods*
-
Hydrophobic and Hydrophilic Interactions
-
Kinetics
-
Magnetic Resonance Spectroscopy
-
Mice
-
Micelles
-
Microscopy, Electron, Transmission
-
Particle Size
-
Polyethylene Glycols / chemical synthesis*
-
Polyethylene Glycols / pharmacology
-
Rhodamines / analysis
-
Rifampin / chemistry
-
Rifampin / metabolism
Substances
-
Biocompatible Materials
-
Delayed-Action Preparations
-
Drug Carriers
-
Micelles
-
Rhodamines
-
monomethoxypolyethyleneglycol-polylactide block copolymer
-
Polyethylene Glycols
-
rhodamine B
-
Rifampin