Abstract
Three novel deoxyribofuranosyl indole derivatives, FG050227 (1), FG050223 (2) and FG050204 (3), were identified as antimicrobial agents effective against Gram-positive bacterial strains and some fungi. The MIC values of (1), (2) and (3) against methicillin-resistant Staphylococcus aureus were 3.0, 6.0 and 13 μg ml⁻¹, respectively. Compounds 1 and 3 had bactericidal activity against exponentially growing S. aureus and inhibited biosynthesis of peptidoglycan, protein, RNA and DNA. Compound 2 was bacteriostatic and inhibited the biosynthesis of protein and RNA. The results indicated that deoxyribofuranosyl indole derivatives could be potential lead compounds for the development of antimicrobial agents.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / pharmacology*
-
Fungi / drug effects*
-
Gram-Positive Bacteria / drug effects*
-
Humans
-
Indoles / chemical synthesis
-
Indoles / chemistry
-
Indoles / pharmacology*
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Methicillin-Resistant Staphylococcus aureus / growth & development
-
Methicillin-Resistant Staphylococcus aureus / metabolism
-
Microbial Sensitivity Tests
-
Staphylococcus aureus / drug effects
-
Staphylococcus aureus / growth & development
-
Staphylococcus aureus / metabolism
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Indoles