Pathology in essential tremor

Abstract

The pathology of essential tremor (ET) is increasingly being studied. The main findings include a reduction in cerebellar Purkinje cells, other pathological changes of cerebellar degeneration and restricted Lewy bodies in the locus ceruleus. This paper will review those findings and put them into context with clinical studies in ET and findings in neurodegenerative disorders such as Parkinson's disease.