Abstract
The topical antiinflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-alpha and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits antiinflammatory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Gene Expression Regulation / drug effects
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Inflammation / drug therapy
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Inflammation / metabolism
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Interleukin-6 / blood
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Interleukin-6 / genetics
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Interleukin-6 / metabolism*
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Mice
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Myrtus / metabolism*
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Oils, Volatile / administration & dosage
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Oils, Volatile / chemistry
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Oils, Volatile / pharmacology*
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Peroxidase / metabolism
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Plant Leaves / chemistry
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Plant Oils / administration & dosage
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Plant Oils / chemistry
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Plant Oils / pharmacology*
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Rats
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Tumor Necrosis Factor-alpha / blood
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Anti-Inflammatory Agents
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Interleukin-6
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Oils, Volatile
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Plant Oils
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Tumor Necrosis Factor-alpha
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Peroxidase