Abstract
Mutually orthogonal tetrazine–transcyclooctene and azide–cyclooctyne cycloaddition reactions were used simultaneously for the bioorthogonal labeling of two different live cell populations in the same culture. These small-molecule probes show good chemical reactivity and can be readily incorporated into biological systems.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkynes / chemistry
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal, Humanized / chemistry
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Antibodies, Monoclonal, Humanized / pharmacology
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Azides / chemistry
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Cell Line, Tumor
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Cetuximab
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Coculture Techniques
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Contrast Media / chemistry*
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Contrast Media / pharmacology
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ErbB Receptors / chemistry
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ErbB Receptors / metabolism
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Fluorescent Dyes / chemistry
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Humans
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Microscopy, Fluorescence
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Receptor, ErbB-2 / chemistry
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Receptor, ErbB-2 / metabolism
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Trastuzumab
Substances
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Alkynes
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Azides
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Contrast Media
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Fluorescent Dyes
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ERBB2 protein, human
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ErbB Receptors
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Receptor, ErbB-2
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Trastuzumab
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Cetuximab