Phenolic compounds of Abies nephrolepis and their NO production inhibitory activities

Chem Biodivers. 2011 Dec;8(12):2299-309. doi: 10.1002/cbdv.201000373.

Abstract

Two new, i.e., 1 and 2, and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D- and 2D-NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC(50) value of 13.7 μg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abies / chemistry*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Cell Line
  • Cell Survival / drug effects
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Phenols / isolation & purification*
  • Phenols / pharmacology
  • Phenols / toxicity
  • Plant Components, Aerial / chemistry
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Phenols
  • Plant Extracts
  • Nitric Oxide