Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives

Mol Divers. 2012 May;16(2):231-40. doi: 10.1007/s11030-011-9348-8. Epub 2011 Dec 11.

Abstract

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Click Chemistry / methods
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Phthalazines / chemical synthesis*
  • Phthalazines / chemistry

Substances

  • Phthalazines