[A new human leukocyte antigen class I allele, HLA- B*52:11]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Dec;28(6):712-5. doi: 10.3760/cma.j.issn.1003-9406.2011.06.026.
[Article in Chinese]

Abstract

Objective: To identify and confirm a novel HLA allele.

Methods: A new human leukocyte antigen class I allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).

Results: The novel HLA-B*52 allele was identical to B*52:01:01 with an exception of one base substitution at position 583 of exon 3 where a C was changed to T resulting in codon 195 changed from CAC(H) to TAC(Y).

Conclusion: A new HLA class I allele, B*52:11, is identified, and is named officially by the WHO Nomenclature Committee.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Alleles*
  • Amino Acid Sequence
  • Base Sequence
  • Genotype
  • HLA-B Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Analysis, DNA

Substances

  • HLA-B Antigens