Aptamer optical biosensor without bio-breakage using upconversion nanoparticles as donors

Chem Commun (Camb). 2012 Jan 28;48(8):1156-8. doi: 10.1039/c2cc16817k. Epub 2011 Dec 12.

Abstract

LRET-based optical biosensor of an aptamer-upconversion conjugate was constructed. It is demonstrated that photosensitized breakage and damage of aptamers are eliminated by employing UCNPs as donors, and the as-designed biosensor is specific and sensitive in the detection of ATP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aptamers, Nucleotide / chemistry*
  • Aptamers, Nucleotide / genetics
  • Base Sequence
  • Biosensing Techniques / methods*
  • Luminescent Measurements
  • Nanoparticles / chemistry*
  • Optical Phenomena*

Substances

  • Aptamers, Nucleotide