Copper-free click--a promising tool for pre-targeted PET imaging

Chem Commun (Camb). 2012 Jan 25;48(7):991-3. doi: 10.1039/c1cc16220a. Epub 2011 Dec 7.

Abstract

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [(18)F]2-fluoroethylazide ([(18)F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry
  • Animals
  • Azides / chemistry
  • Azides / pharmacokinetics*
  • Cyclization
  • Fluorine Radioisotopes / chemistry
  • Fluorine Radioisotopes / pharmacokinetics*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Positron-Emission Tomography / methods*
  • Tissue Distribution

Substances

  • 2-fluoroethylazide
  • Alkynes
  • Azides
  • Fluorine Radioisotopes