Risk factors for pre-eclampsia in Mulago Hospital, Kampala, Uganda

Trop Med Int Health. 2012 Apr;17(4):480-7. doi: 10.1111/j.1365-3156.2011.02926.x. Epub 2011 Dec 13.

Abstract

Objective: Pre-eclampsia contributes significantly to maternal, foetal and neonatal morbidity and mortality. The risk factors for pre-eclampsia have not been well documented in Uganda. In this paper, we describe the risk factors for pre-eclampsia in women attending antenatal clinics at Mulago Hospital, Kampala.

Methods: This casecontrol study was conducted from 1st May 2008 to 1st May 2009. 207 women with pre-eclampsia were the cases, and 352 women with normal pregnancy were the controls. The women were 15-39 years old, and their gestational ages were 20 weeks or more. They were interviewed about their socio-demographic characteristics, past medical history and, their past and present obstetric performances.

Results: The risk factors were low plasma vitamin C (OR 3.19, 95% CI: 1.54-6.61), low education level (OR 1.67, 95% CI: 1.12-2.48), chronic hypertension (OR 2.29, 95% CI 1.12-4.66), family history of hypertension (OR 2.25, 95% CI: 1.53-3.31) and primiparity (OR 2.76, 95% CI: 1.84-4.15) and para≥5 (3.71, 95% CI:1.84-7.45).

Conclusion: The risk factors identified are similar to what has been found elsewhere. Health workers need to identify women at risk of pre-eclampsia and manage them appropriately so as to prevent the maternal and neonatal morbidity and mortality associated with this condition.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Comorbidity
  • Confidence Intervals
  • Female
  • Humans
  • Hypertension / epidemiology
  • Male
  • Maternal Welfare / statistics & numerical data*
  • Odds Ratio
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Prenatal Care / methods*
  • Risk Factors
  • Socioeconomic Factors
  • Uganda
  • Women's Health*
  • Young Adult