Cyclam functionalization through isocyanate insertion in Zr-N bonds

Luis G Alves; Ana M Martins

doi:10.1021/ic201750y

Cyclam functionalization through isocyanate insertion in Zr-N bonds

Inorg Chem. 2012 Jan 2;51(1):10-2. doi: 10.1021/ic201750y. Epub 2011 Dec 7.

Authors

Luis G Alves¹, Ana M Martins

Affiliation

¹ Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Avenida Rovisco Pais 1, 1049-001 Lisboa, Portugal.

PMID: 22148870
DOI: 10.1021/ic201750y

Abstract

The insertion of isocyanates in (Bn(2)Cyclam)ZrX(2) is regioselective; (Bn(2)Cyclam)Zr(OR)(2) produces urea-like moieties by the insertion of RN═C═O in the Zr-N(amido) bonds of the cyclam ring. Depending on the bulkiness of the isocyanate R groups, O- and N-bound ureates are formed. (Bn(2)Cyclam)Zr(NH(t)Bu)(2) reacts with MesN═C═O at the terminal Zr-N bonds.