Abstract
Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology*
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Dose-Response Relationship, Drug
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Inhibitory Concentration 50
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Isoflavones / chemistry
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Isoflavones / isolation & purification
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Lauraceae / chemistry*
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Lipopolysaccharides / pharmacology
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Molecular Structure
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NF-kappa B / drug effects
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Nitric Oxide Synthase Type II / drug effects
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Plant Roots / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
Substances
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Alkaloids
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Anti-Inflammatory Agents, Non-Steroidal
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Carbolines
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Isoflavones
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Lipopolysaccharides
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NF-kappa B
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Sesquiterpenes
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prunetin
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Nitric Oxide Synthase Type II