Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity

J Nat Prod. 2011 Dec 27;74(12):2489-96. doi: 10.1021/np100874f. Epub 2011 Dec 7.

Abstract

Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Carbolines / chemistry
  • Carbolines / isolation & purification*
  • Carbolines / pharmacology*
  • Dose-Response Relationship, Drug
  • Inhibitory Concentration 50
  • Isoflavones / chemistry
  • Isoflavones / isolation & purification
  • Lauraceae / chemistry*
  • Lipopolysaccharides / pharmacology
  • Molecular Structure
  • NF-kappa B / drug effects
  • Nitric Oxide Synthase Type II / drug effects
  • Plant Roots / chemistry
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*

Substances

  • Alkaloids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Carbolines
  • Isoflavones
  • Lipopolysaccharides
  • NF-kappa B
  • Sesquiterpenes
  • prunetin
  • Nitric Oxide Synthase Type II