Total synthesis of penostatin B

Kosuke Fujioka; Hiromasa Yokoe; Masahiro Yoshida; Kozo Shishido

doi:10.1021/ol203021c

Total synthesis of penostatin B

Org Lett. 2012 Jan 6;14(1):244-7. doi: 10.1021/ol203021c. Epub 2011 Dec 6.

Authors

Kosuke Fujioka¹, Hiromasa Yokoe, Masahiro Yoshida, Kozo Shishido

Affiliation

¹ Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.

PMID: 22145647
DOI: 10.1021/ol203021c

Abstract

The first total synthesis of penostatin B has been accomplished by using a highly diastereoselective Pauson-Khand reaction and an efficient relay ring-closing metathesis for the construction of the basic carbon skeleton of the natural product as the key steps.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzopyrans / chemical synthesis*
Carbon / chemistry
Molecular Structure
Stereoisomerism

Substances

Benzopyrans
penostatin B
Carbon