Abstract
Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid esters, 1-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16-49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16, 17, 23, 24, 31, 32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.
MeSH terms
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Aminophenols / chemistry
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Aniline Compounds / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chemistry Techniques, Synthetic
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Cyclization
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Drug Screening Assays, Antitumor
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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Microbial Sensitivity Tests
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Structure-Activity Relationship
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Sulfonamides / chemistry*
Substances
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4-chloro-2-mercaptobenzenesulfonamide
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Aminophenols
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Aniline Compounds
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Anti-Bacterial Agents
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Antineoplastic Agents
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Sulfonamides
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2-aminothiophenol
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2-aminophenol