An adult case of acute lymphoblastic leukemia with necrotizing leukoencephalopathy

Jpn J Med. 1990 Jan-Feb;29(1):56-60. doi: 10.2169/internalmedicine1962.29.56.

Abstract

A 19-year-old man with common acute lymphoblastic leukemia (ALL) developed necrotizing leukoencephalopathy (NL) after extensive chemotherapy and irradiation. Clinicians should exercise care in the treatment of leukemia, since chemotherapy has shown a trend of becoming more intensive, and the survival time of patients with leukemia is being extended.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Leukoencephalopathy, Progressive Multifocal / chemically induced*
  • Leukoencephalopathy, Progressive Multifocal / diagnostic imaging
  • Male
  • Methotrexate / adverse effects*
  • Necrosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnostic imaging
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Radionuclide Imaging
  • Tomography, X-Ray Computed

Substances

  • Methotrexate