Abstract
Enterococcus faecalis NKR-4-1 isolated from pla-ra produces a novel two-peptide lantibiotic, termed enterocin W, comprising Wα and Wβ. The structure of enterocin W exhibited similarity with that of plantaricin W. The two peptides acted synergistically, and their order of binding to the cell membrane was important for their inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology
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Bacteriocins / chemistry
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Bacteriocins / isolation & purification*
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Bacteriocins / metabolism*
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Bacteriocins / pharmacology
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Base Sequence
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / isolation & purification
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Bridged-Ring Compounds / metabolism
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Bridged-Ring Compounds / pharmacology
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Cell Membrane / metabolism
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Dipeptides / chemistry
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Dipeptides / isolation & purification
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Dipeptides / metabolism
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Dipeptides / pharmacology
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Drug Synergism
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Enterococcus faecalis / metabolism*
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Genes, Bacterial / genetics
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Molecular Sequence Data
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Sequence Analysis, DNA
Substances
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Anti-Bacterial Agents
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Bacteriocins
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Bridged-Ring Compounds
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DNA, Bacterial
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Dipeptides
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enterocin