Acute central nervous system symptoms caused by ibuprofen in connective tissue disease

B Agus; J Nelson; N Kramer; S S Mahal; E D Rosenstein

Acute central nervous system symptoms caused by ibuprofen in connective tissue disease

J Rheumatol. 1990 Aug;17(8):1094-6.

Authors

B Agus¹, J Nelson, N Kramer, S S Mahal, E D Rosenstein

Affiliation

¹ Department of Medicine, NYU School of Medicine, NY.

PMID: 2213786

Abstract

We describe 2 cases of acute encephalopathy in patients with connective tissue disease caused by small doses of ibuprofen. In addition to aseptic meningitis, both patients had altered mental status and focal neurologic signs, ophthalmoplegia in one and hemiparesis in the other. The spectrum of neurologic manifestations of ibuprofen hypersensitivity is reviewed.

Publication types

Case Reports

MeSH terms

Acute Disease
Adult
Central Nervous System Diseases / chemically induced*
Connective Tissue Diseases / drug therapy*
Drug Hypersensitivity / etiology*
Female
Hemiplegia / chemically induced
Humans
Ibuprofen / adverse effects*
Male
Meningitis, Aseptic / chemically induced
Middle Aged
Ophthalmoplegia / chemically induced
Raynaud Disease / drug therapy

Substances

Ibuprofen