Aromatase inhibitors in the treatment of recurrent ovarian granulosa cell tumors: brief report and review of the literature

Abstract

Granulosa cell tumors are ovarian sex cord stromal cancers that are unique for their indolent nature and late recurrence. Standard treatment regimens utilized include surgery, chemotherapy, and radiotherapy. However, hormonal suppression with aromatase inhibitors, which have shown promising results, may be a viable alternative to these modalities. We present a heavily pre-treated, multi-operated patient who experienced significant tumor shrinkage following treatment with an aromatase inhibitor for her recurrent granulosa cell tumor.