Mechanism of nitric oxide production in macrophages treated with medicinal mushroom extracts (review)

Int J Med Mushrooms. 2011;13(1):1-6. doi: 10.1615/intjmedmushr.v13.i1.10.

Abstract

Nitric oxide (NO) is a gas with highly reactive radicals and is an important signal molecule in living organisms with diverse pathophysiological functions. Inducible NO synthase (iNOS) can be expressed in macrophages and is able to induce NO production. Studies have proposed that mushroom extracts can promote or inhibit NO production in macrophages through acting on iNOS, nuclear factor kappa B, and other signaling pathways. This article is dedicated to the mechanism of mushroom extracts affecting NO secretion in macrophages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Agaricales / chemistry*
  • Complex Mixtures / pharmacology*
  • Humans
  • Macrophages / drug effects*
  • Macrophages / enzymology
  • Macrophages / metabolism
  • NF-kappa B / drug effects*
  • NF-kappa B / genetics
  • NF-kappa B / metabolism
  • Nitric Oxide / biosynthesis*
  • Nitric Oxide Synthase Type II / drug effects*
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism
  • RNA, Messenger / genetics
  • Signal Transduction / drug effects

Substances

  • Complex Mixtures
  • NF-kappa B
  • RNA, Messenger
  • Nitric Oxide
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II