A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities

Hongyu Zhang; Hongpeng Wang; Hongli Cui; Zonggang Li; Zeping Xie; Yang Pu; Fuchao Li; Song Qin

doi:10.3390/md9091502

A new anthracene derivative from marine Streptomyces sp. W007 exhibiting highly and selectively cytotoxic activities

Mar Drugs. 2011;9(9):1502-1509. doi: 10.3390/md9091502. Epub 2011 Sep 9.

Authors

Hongyu Zhang^{1

2}, Hongpeng Wang³, Hongli Cui¹, Zonggang Li⁴, Zeping Xie¹, Yang Pu¹, Fuchao Li⁵, Song Qin¹

Affiliations

¹ Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
² Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
³ Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany.
⁴ Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China.
⁵ Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

Abstract

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.

Keywords: Streptomyces; anthracene; cytotoxicity; structure establishment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthracenes / chemistry
Anthracenes / isolation & purification*
Anthracenes / pharmacology
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Antifungal Agents / pharmacology
Cell Line, Tumor
Humans
Magnetic Resonance Spectroscopy
Microbial Viability / drug effects
Streptomyces / metabolism*
Water Microbiology*

Substances

Anthracenes
Antibiotics, Antineoplastic
Antifungal Agents