Capilloquinol: a novel farnesyl quinol from the Dongsha atoll soft coral Sinularia capillosa

Shi-Yie Cheng; Ki-Jhih Huang; Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md9091469

Capilloquinol: a novel farnesyl quinol from the Dongsha atoll soft coral Sinularia capillosa

Mar Drugs. 2011;9(9):1469-1476. doi: 10.3390/md9091469. Epub 2011 Aug 30.

Authors

Shi-Yie Cheng¹, Ki-Jhih Huang¹, Shang-Kwei Wang², Chang-Yih Duh^{1

3}

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
³ Centers for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Abstract

Capilloquinol (1), possessing an unprecedented farnesyl quinoid skeleton, was isolated from the Dongsha Atoll soft coral Sinularia capillosa. The structure of capilloquinol was elucidated by extensive analysis of spectroscopic data. The cytotoxicity and antiviral activity against human cytomegalovirus of 1 was evaluated in vitro.

Keywords: Sinularia capillosa; cytotoxicity; farnesyl quinoid; soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / metabolism*
Antineoplastic Agents / pharmacology
Antiviral Agents / pharmacology
Cell Line, Tumor
Humans
Hydroquinones / chemistry
Hydroquinones / isolation & purification
Hydroquinones / pharmacology*
Magnetic Resonance Spectroscopy

Substances

Antineoplastic Agents
Antiviral Agents
Hydroquinones
capilloquinol