Abstract
Two new antimicrobial chlorinated cyclopentenones, palmaenones A (1) and B (2) were isolated from the culture broth of discomycete Lachnum palmae (NBRC-106495), and the structures of 1 and 2 were elucidated by spectroscopic data and the stereochemistry of 1 was directly determined by a single-crystal X-ray diffraction analysis. Palmaenones A (1) and B (2) are cyclopentenones containing three chlorines. Compound 1 exhibited potent antimicrobial activity against Micrococcus luteus, Mycobacterium smegmatis, Escherichia coli, Xanthomonas campestris, and Mucor racemosus, while the activities of compound 2 were weaker than 1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Ascomycota / chemistry*
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Bacteria / drug effects
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Bacterial Infections / drug therapy
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Crystallography, X-Ray
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Cyclopentanes / chemistry*
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Cyclopentanes / isolation & purification
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Cyclopentanes / pharmacology*
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Escherichia coli / drug effects
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Halogenation
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Humans
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Micrococcus luteus / drug effects
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Models, Molecular
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Mucor / drug effects
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Mucormycosis / drug therapy
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Mycobacterium smegmatis / drug effects
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Xanthomonas campestris / drug effects
Substances
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Anti-Infective Agents
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Cyclopentanes
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cyclopentenone